Pharmaceutical Applications on Columns Packed with Sub-2 m Particles
نویسندگان
چکیده
منابع مشابه
Rapid Analysis of the Beta Blocker Pindolol, using a USP Method with HPLC Columns Packed with Sub-2-Micron Particles
Pindolol is a beta blocker which helps to lower blood pressure and may possibly also alleviate depression. With potentially even more uses for this drug product it is important to develop faster analyses of it. Using pindolol and a USP method, this study demonstrates how use of short HPLC columns packed with sub-2-micron support particles (ZORBAX SB-CN (L10) columns) provide easy scalability to...
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Many different strategies of reversed phase high performance liquid chromatographic (RP-HPLC) method development are used today. This paper describes a strategy for the systematic development of ultrahigh-pressure liquid chromatographic (UHPLC or UPLC) methods using 5cmx2.1mm columns packed with sub-2microm particles and computer simulation (DryLab((R)) package). Data for the accuracy of comput...
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• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version ...
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This paper presents results concerning the validation of a recently developed packing algorithm. The basic ethos of this algorithm, known as DigiPac, is to use threedimensional methods to digitise particle shapes, and to use this digital information directly in computations of how particles pack together without further conversion or the need for modelling. A variety of simulations of packed co...
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For a packed bed in a distillation column, fmax is the maximum fractional liquid maldistribution that can be tolerated in a parallel column model whilst still being able to achieve the design separation. It was previously shown that fmax can be easily calculated from a conventional column simulation output and it is a measure of the sensitivity of a packed bed to maldistribution. In this paper,...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2008
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/46.3.199